▼Course List

Medical Microbiology and Infectious Diseases

personal history

1988.04 ? 1994.03 Nagasaki Univ. School of Medicine.
1994.07 ? 1996.03 Staff resident in Nagasaki University Hospital
1996.04 ? 2000.03 Postgraduate School, Laboratory Medicine, Nagasaki University School of Medicine
2000.05 ? 2003.07 Clinical Mycology Section, LCI/NIAID, National Institutes of Health
2003.08 ? 2004.06 Director, Nagasaki Prefectural Clinic
2004.08 ? 2005.03 Toranomon Hospital
2005.04 ? 2009.03 Assistant Professor, Second Department of Internal Medicine, Nagasaki University School of Medicine
2009.04 ? 2009.09 Molecular Microbiology Section, LCID/NIAID, National Institutes of Health
2009.10 ? 2011.05 Assistant Professor, Department of Molecular Micrology and Immunology, Nagaskai University Graduate School of Bilmedical Sciences
2011.06 ? 2014.02 Senior Assistant Professor, Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences
2013.01 ? Present Derector, Nagaskai University Infection Control and Education Center
2014.03 ? Present Professor, Department of Infectious Diseases, Unit of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences

works/thesis

Yamamoto Y, Izumikawa K, Morinaga Y, Nakamura S, Kurihara S, Imamura Y, Miyazaki T, Tsukamoto M, Kakeya H, Yanagihara K, Yasuoka A, Kohno S. Prospective randomized comparison study of piperacillin/tazobactam and meropenem for healthcare-associated pneumonia in Japan. J Infect Chemother. 2013 Jan 24

Izumikawa K, Tashiro M, Kohno S. Management of chronic pulmonary aspergillosis. Ann N Y Acad Sci. 2012 Dec;1272:40-8.

Kohno S, Izumikawa K, Yoshida M, Takesue Y, Oka S, Kamei K, Miyazaki Y, Yoshinari T, Kartsonis NA, Niki Y. A double-blind comparative study of the safety and efficacy of caspofungin versus micafungin in the treatment of candidiasis and aspergillosis. Eur J Clin Microbiol Infect Dis. 2012 Oct 3.

Takazono T, Izumikawa K, Yoshioka S, Matsuo N, Yamakawa M, Suyama N, Kohno S. Possible pulmonary cryptococcosis in a patient with Crohn's disease during anti-tumor necrosis factor-alpha treatment: a case report and literature review. Jpn J Infect Dis. 2012 Sep;65(5):461-4.

Mihara T, Izumikawa K, Kakeya H, Ngamskulrungroj P, Umeyama T, Takazono T, Tashiro M, Nakamura S, Imamura Y, Miyazaki T, Ohno H, Yamamoto Y, Yanagihara K, Miyzaki Y, Kohno S. Multilocus sequence typing of Cryptococcus neoformans in non-HIV associated cryptococcosis in Nagasaki, Japan. Med Mycol. 2012 Aug 17. [Epub ahead of print]

Nagaoka K, Izumikawa K, Yamamoto Y, Yanagihara K, Ohkusu K, Kohno S. A case of multiple lung abscesses caused by Actinomyces graevenitzii mimicking acute pulmonary coccidioidomycosis. J Clin Microbiol. 2012 Sep;50(9):3125-8.

Tashiro M, Izumikawa K, Hirano K, Ide S, Mihara T, Hosogaya N, Takazono T, Morinaga Y, Nakamura S, Kurihara S, Imamura Y, Miyazaki T, Nishino T, Tsukamoto M, Kakeya H, Yamamoto Y, Yanagihara K, Yasuoka A, Tashiro T, Kohno S. Correlation between triazole treatment history and susceptibility in clinically isolated Aspergillus fumigatus. Antimicrob Agents Chemother. 2012 56(9):4870-5.

Izumikawa K, Yamamoto Y, Mihara T, Takazono T, Morinaga Y, Kurihara S, Nakamura S, Imamura Y, Miyazaki T, Nishino T, Tsukamoto M, Kakeya H, Yanagihara K, Mine M, Yasuoka A, Tashiro T, Kohno S.　Bronchoalveolar lavage galactomannan for the diagnosis of chronic pulmonary aspergillosis.　Med Mycol. 2012 Nov;50(8):811-7

Yamamoto Y, Izumikawa K, Hosogaya N, Morinaga Y, Nakamura S, Imamura Y, Miyazaki T, Sakamoto N, Ishimatu Y, Kakeya H, Yanagihara K, Yasuoka A, Kohno S. A case of refractory chronic respiratory tract infection due to Pseudomonas aeruginosa successfully controlled by combination of clarithromycin and azithromycin. Intern Med. 2012;51(11):1383-6.

Yamamoto Y, Izumikawa K, Hashiguchi K, Fukuda Y, Kobayashi T, Kondo A, Inoue Y, Morinaga Y, Nakamura S, Imamura Y, Miyazaki T, Kakeya H, Yanagihara K, Kohno S. The efficacy and safety of high-dose arbekacin sulfate therapy (once-daily treatment) in patients with MRSA infection.　J Infect Chemother. 2012 Apr;18(2):241-6.

Izumikawa K, Yamamoto Y, Yanagihara K, Kiya T, Matsuda J, Morinaga Y, Kurihara S, Nakamura S, Imamura Y, Miyazaki T, Nishino T, Tsukamoto M, Kakeya H, Yasuoka A, Tashiro T, Kamihira S, Kohno S.　Active surveillance of methicillin-resistant Staphylococcus aureus with the BD GeneOhm MRSA? assay in a respiratory ward in Nagasaki, Japan.　Jpn J Infect Dis. 2012 Jan; 65(1):33-6.

Tashiro M, Izumikawa K, Minematsu A, Hirano K, Iwanaga N, Ide S, Mihara T, Hosogaya N, Takazono T, Morinaga Y, Nakamura S, Kurihara S, Imamura Y, Miyazaki T, Nishino T, Tsukamoto M, Kakeya H, Yamamoto Y, Yanagihara K, Yasuoka A, Tashiro T, Kohno S. Antifungal susceptibilities of Aspergillus fumigatus clinical isolates in Nagasaki, Japan. Antimicrob Agents Chemother. 2012 56(1):584-587

Gyotoku H, Izumikawa K, Ikeda H, Takazono T, Morinaga Y, Nakamura S, Imamura Y, Nishino T, Miyazaki T, Kakeya H, Yamamoto Y, Yanagihara K, Yasuoka A, Yaguchi T, Ohno H, Miyazaki Y, Kamei K, Kanda T, Kohno S.　A case of bronchial aspergillosis caused by Aspergillus udagawae and its mycological features.　Med Mycol. 2011 Dec 13.

Izumikawa K, Motoi N, Takaya H, Miyamoto A, Eishi Y, Yoshimura K, Kishi K.　A case of concurrent sarcoidosis, aortitis syndrome and Crohn's disease.　Intern Med. 2011; 50(23):2915-7. Epub 2011 Dec 1.

Takazono T, Izumikawa K, Nagayoshi Y, Tanaka A, Mihara T, Kosai K, Saijo T, Imamura Y, Miyazaki T, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Kamihira S, Kohno S. Evaluation of the cica fungi test Candida, a novel serum Candida mannan antigen kit, and its comparison with cand-tec in candidemia patients. Jpn J Infect Dis. 2011 64(2):116-20.

Kohno S, Izumikawa K, Kakeya H, Miyazaki Y, Ogawa K, Amitani R, Niki Y, Kurashima A. Clinical efficacy and safety of Micafungin in Japanese patients with chronic pulmonary aspergillosis: a prospective observational study. Med Mycol. 201149(7):688-93.

Tashiro T, Izumikawa K, Tashiro M, Takazono T, Morinaga Y, Yamamoto K, Imamura Y, Miyazaki T, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Yasuoka A, Kohno S. Diagnostic significance of Aspergillus species isolated from respiratory samples in an adult pneumology ward. Med Mycol. 2011 49(6):581-7.

Izumikawa K, Kohno Y, Izumikawa K, Hara K, Hayashi H, Maruyama H, Kohno S.　Eosinophilic pneumonia due to visceral larva migrans possibly caused by Ascaris suum: a case report and review of recent literatures.　Jpn J Infect Dis. 2011; 64(5):428-32.

Kohno S, Izumikawa K. Posaconazole for chronic pulmonary aspergillosis: The next strategy against the threat of azole-resistant Aspergillus infection. Clin Infect Dis. 2010 51(12):1392-4.

Izumikawa K, Takazono T, Kohno S. Chronic aspergillus infections of the respiratory tract: diagnosis, management and antifungal resistance. Curr Opin Infect Dis. 2010; 23(6):584-9

Kohno S, Izumikawa K, Ogawa K, Kurashima A, Okimoto N, Amitani R, Kakeya H, Niki Y, Miyazaki Y. Intravenous micafungin versus voriconazole for chronic pulmonary aspergillosis: a multicenter trial in Japan. J Infection. 2010; 61(5):410-8.

Izumikawa K, Nakano K, Kurihara S, Imamura Y, Yamamoto K, Miyazaki T, Sakamoto N, Seki M, Ishimatsu Y, Kakeya H, Yamamoto Y, Yanagihara K, Tsuchiya T, Yamasaki N, Tagawa T, Mukae H, Nagayasu T, Kohno S. Diffuse alveolar hemorrhage following itraconazole injection. Intern Med. 2010; 49(5):497-500.

Takazono T, Izumikawa K, Mihara T, Kosai K, Saijo T, Imamura Y, Miyazaki T, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Kohno S. Efficacy of combination antifungal therapy with intraperitoneally administered micafungin and aerosolized liposomal amphotericin B against murine invasive pulmonary aspergillosis. Antimicrob Agents Chemother. 2009 Aug; 53(8):3508-10.

Izumikawa K, Akamatsu S, Kageyama A, Okada K, Kazuyama Y, Takayanagi N, Nakamura S, Inoue Y, Higashiyama Y, Fukushima K, Ishida T, Sawai T, Yoshimura K, Nakahama C, Ohmichi M, Kakugawa T, Nishioka Y, Aoki N, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Kohno S. Evaluation of a rapid immunochromatographic ODK0501 assay for detecting Streptococcus pneumoniae antigen in sputum samples from patients with lower respiratory tract infection. Clin Vaccine Immunol. 2009 16(5):672-8.

Izumikawa K, Tomiyama Y, Ishimoto H, Sakamoto N, Imamura Y, Seki M, Sawai T, Kakeya H, Yamamoto Y, Yanagihara K, Mukae H, Yoshimura K, Kohno S. Unique mutations of the cystic fibrosis transmembrane conductance regulator gene of three cases of cystic fibrosis in Nagasaki, Japan. Intern Med 2009 48(15):1327-31

Saijo T, Izumikawa K, Takazono T, Kosai K, Kurihara S, Nakamura S, Imamura Y, Miyazaki T, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Miyazaki Y, Fukushima K, Kohno S. A case of Legionella pneumophila pneumonia followed by invasive aspergillosis. Jpn J Infect Dis. 2008 Sep; 61(5):379-81.

Izumikawa K, Zhao Y, Motoshima K, Takazono T, Saijo T, Kurihara S, Nakamura S, Miyazaki T, Seki M, Kakeya H, Yamamoto Y, Yanagihara K, Miyazaki Y, Hayashi T, Kohno S. A case of pulmonary cryptococcosis followed by pleuritis in an apparently immunocompetent patient during fluconazole treatment. Med Mycol. 2008 46(6):595-599.

Izumikawa K, Ohtsu Y, Kawabata M, Takaya H, Miyamoto A, Sakamoto S, Kishi K, Tsuboi E, Homma S, Yoshimura K. Clinical efficacy of micafungin for chronic pulmonary aspergillosis.　Med Mycol. 2007 May; 45(3):273-8.

Izumikawa K, Morinaga Y, Kondo A, Hara K, Izumikawa K, Miyazaki Y, Kohno S, Igari N, Akaboshi M, Kawakami J, Eguchi K. Adult Still's disease associated with cytomegalovirus infection.　J Infect Chemother. 2007 Apr; 13(2):114-7.

Izumikawa K, Morinaga Y, Izumikawa K, Hara K, Kohno S. A case of splenic abscess during treatment of interstitial pneumonia. Jpn J Infect Dis. 2006 Oct;59(5):320-2.

Tsai HF, Bard M, Izumikawa K, Krol AA, Sturm AM, Culbertson NT, Pierson CA, Bennett JE. Candida glabrata erg1 mutant with increased sensitivity to azoles and to low oxygen tension. Antimicrob Agents Chemother. 48:2483-9 2004.

Bennett JE, Izumikawa K, Marr KA. Mechanism of increased fluconazole resistance in Candida glabrata during prophylaxis. Antimicrob Agents Chemother. 48:1773-7 2004.

Yamanouchi H, Izumikawa K, Hisamatsu T, Yoshinaga M, Sasaki E, Izumikawa K, Hayakawa T, Hara K, Maruyama S, Ohtani H, Shimokawa I. [A case of Bartonella henselae infection from a dog] Kansenshogaku Zasshi. 78:270-3 2004.

Maruyama S, Izumikawa K, Miyashita M, Kabeya H, Mikami T, Yamanouchi H, Sasaki E, Yoshida H, Izumikawa K. First isolation of Bartonella henselae type I from a cat-scratch disease patient in Japan and its molecular analysis. Microbiol Immunol. 48:103-9 2004.

Aoki S, Hirakata Y, Miyazaki Y, Izumikawa K, Yanagihara K, Tomono K, Yamada Y, Tashiro T, Kohno S, Kamihira S. Detection of Legionella DNA by PCR of whole-blood samples in a mouse model. J Med Microbiol. 52:325-9 2003.

Izumikawa K, Kakeya H, Tsai HF, Grimberg B, Bennett JE. Function of Candida glabrata ABC transporter gene, PDH1. Yeast. 20:249-61 2003.

Izumikawa K, Hirakata Y, Yamaguchi T, Yoshida R, Nakano M, Matsuda J, Mochida C, Maesaki S, Tomono K, Yamada Y, Tashiro T, Kohno S, and Kamihira S. Analysis of genetic relationships and antimicrobial susceptibility of verotoxin-producing Escherichia coli strains isolated in Nagasaki Prefecture, Japan in 1996. Microbiol Immunol. 42:677-81 1998.

Izumikawa K, Hirakata Y, Yamaguchi T, Takemura H, Maesaki S, Tomono K, Igimi S, Kaku M, Yamada Y, Kohno S, and Kamihira S. Escherichia coli O157 interactions with human intestinal Caco-2 cells and the influence of fosfomycin. J Antimicrob Chemother. 42:341-7 1998.

Hirakata Y, Izumikawa K, Yamaguchi T, Takemura H, Tanaka H, Yoshida R, Matsuda J, Nakano M, Tomono K, Maesaki S, Kaku M, Yamada Y, Kamihira S, and Kohno S. Rapid detection and evaluation of clinical characteristics of emerging multiple-drug-resistant gram-negative rods carrying the metallo-beta lactamase gene blaIMP. Antimicrob Agents Chemother 42:2006-11 1998.

Hirakata Y, Izumikawa K, Yamaguchi T, Igimi S, Furuya N, Maesaki S, Tomono K, Yamada Y, Kohno S, Yamaguchi K, and Kamihira S. Adherence to and penetration of human intestinal Caco-2 epithelial cell monolayers by Pseudomonas aeruginosa. Infect Immun 66:1748-51 1998.

Izumikawa K, Hirakata Y, Yamaguchi T, Yoshida R, Tanaka H, Takemura H, Maesaki S, Tomono K, Kaku M, Izumikawa KI, Kamihira S, and Kohno S. In vitro activities of quinupristin-dalfopristin and the streptogramin RPR 106972 against Mycoplasma pneumoniae. Antimicrob Agents Chemother 42: 698-9 1998.